氨基酸代谢差异(酵母支链氨基酸代谢生物传感器)

閰垫瘝鏀摼姘ㄥ熀閰镐唬璋㈢敓鐗╀紶鎰熷櫒

2022骞?鏈?2鏃?/span>nature communication鎶ラ亾锛岀編鍥芥櫘鏋楁柉椤垮ぇ瀛︾爺绌惰€呭埄鐢ㄩ吙閰掗叺姣嶈浆褰曡皟鑺傚洜瀛怢eu3p寮€鍙戜簡鐢ㄤ簬BCAA浠ｈ阿鐨勫熀鍥犵紪鐮佺敓鐗╀紶鎰熷櫒锛屽彲鐢ㄤ簬鐩戞祴閰垫瘝涓紓涓侀唶鍜屽紓鎴婇唶鐢熶骇銆?/span>

鏀摼姘ㄥ熀閰?Branched-chain amino acid锛孊CAA) 鍖呮嫭缂皑閰搞€佷寒姘ㄩ吀鍜屽紓浜皑閰革紝BCAA浠ｈ阿鍏锋湁澶氱鐢熺悊浣滅敤锛岃繕鍙敤浜庣敓浜у悇绉嶆湁浠峰€肩殑鍖栧鐗╄川銆傜劧鑰岋紝褰撳墠缂轰箯涓撻棬閽堝BCAA琛嶇敓浜у搧鐨勭湡鏍哥敓鐗╀紶鎰熷櫒锛岀敓鐗╀紶鎰熷櫒鍙敤浜庨珮閫氶噺绛涢€夊拰鍔犻€熺粏鑳炲伐鍘傜殑鏋勫缓鍜屽簲鐢ㄣ€?/span>

鍥撅細涓ょBCHA鐢熺墿浼犳劅鍣ㄩ厤缃殑璁捐鍜岃〃寰亅鏉ユ簮锛?/span>nature communication

姝ゆ锛岀爺绌惰€呭埄鐢ㄦ潵鑷吙閰掗叺姣嶇殑杞綍璋冭妭鍥犲瓙Leu3p寮€鍙戝嚭浜嗕竴涓熀鍥犵紪鐮佺殑BCAA浠ｈ阿鐢熺墿浼犳劅鍣紝璇ヤ紶鎰熷櫒杩樺彲鐢ㄤ簬鐩戞祴閰垫瘝鐢熶骇鐨勫紓涓侀唶锛屽紓涓侀唶鏄竴绉嶆潵鑷棘姘ㄩ吀闄嶈В鐨勯唶绫汇€傜爺绌惰€呰繕閫氳繃寰皟灏哃eu3p鐢ㄤ簬鍙︿竴绉嶇敓鐗╀紶鎰熷櫒锛岀洃娴嬩寒姘ㄩ吀琛嶇敓閱団€斺€斿紓鎴婇唶鐨勭敓浜с€傝繖浜涚敓鐗╀紶鎰熷櫒閰嶇疆鍙互鏈夋晥鍦板垎绂婚珮浜ц弻鏍紝骞朵粠绾跨矑浣撳拰缁嗚優璐ㄤ腑鍒嗘灊閾鹃珮绾ч唶(branched-chain higher alcohol锛孊CHA)鐢熺墿鍚堟垚绛涢€変腑璇嗗埆娲绘€у寮虹殑閰躲€傛澶栵紝璇ョ敓鐗╀紶鎰熷櫒杩樺彲鐢ㄤ簬鍗忓姪娑夊強BCAA閫斿緞鐨勪唬璋㈢爺绌讹紝骞朵负寮€鍙戞潵鑷狟CAA浠ｈ阿鐨勫叾浠栦骇鍝佺殑鐢熺墿浼犳劅鍣ㄦ彁渚涗簡钃濆浘銆?/span>

缂栬瘧鏁寸悊|鍚存檽鐕?鐢熺墿绉戞妧鎴樼暐鐮旂┒涓績

鍙傝€冩枃鐚畖Biosensor for branched-chain amino acid metabolism in yeast and applications in isobutanol and isopentanol production 璇嗗埆浜岀淮鐮佸彲棰勮鍘熸枃鈫?/span>

閰垫瘝鏀摼姘ㄥ熀閰镐唬璋㈢敓鐗╀紶鎰熷櫒